Aloe vera research pdf

Antimicrobial activity was recorded significant antimicrobial activity evaluated by measuring the zone of inhibition. Antibacterial and All the experiments were repeated thrice and antifungal activity of the acetone extract was results were recorded. DMSO was used as found to be quite impressive as compared to negative control. Cock 16 studied the antimicrobial activity of A. Result: components. Methanolic extracts of A. DMSO gel extracts of A. The antibacterial activity has been and fungi.

Of which fraction against all the tested bacteria with varied 1 had the broadest antibacterial activity. Agarry activity. The maximum zone of inhibition 13 et al 15 compared the antimicrobial activities of mm for E. Similar to antibacterial, the antifungal mentagraphytes, T. In the present study, we prepared the cold A. Only the gel inhibited vera extracts by using Dimethyl sulfoxide as a the growth of T. Pugh et al 19 and Lawless and Allan 24 possesses inhibitory effects on both P.

Thiruppathi et al 18 against the pathogens viz. They observed the maximum zone of ether and ethanol against Gram positive bacteria inhibition against Bacillus with 23 mm. They B. The against the pathogen E. In contrary in the result showed that more antimicrobial activity in present study we observed maximum zone of ethyl acetate mm and ethanol extract inhibition against the pathogen E.

The least inhibitory effect on petroleum Alemdar and Agaoglu 25 conducted a study to ether extract was 2 mm. Thiruppathi et al 18 prepared the A. After overnight incubation the typhimurium and C. The mixture was filtered through Whatmann No. After evaporation, pellet was pneumoniae, E. The recollect it for further use. Plant powder residue result of the present study supplemented the left after ethanol extraction was sequentially previous observations on the antimicrobial extracted with ethyl acetate, hexane and activity of the A.

They studied the antibacterial activity of establishment of some compounds that could be hexane, ethyl acetate, petroleum ether and used to formulate new and more potent ethanol extract of A.

Studies are positive bacteria B. But in the present study we studied vera gel extracts on some organisms associated the antibacterial and antifungal activity against with human diseases. In addition, Arunkumar and 17 1. Herbal Muthuselvam used three different solvents medicines, A Guide for Healthcare professionals, aqueous, ethanol and acetone to extract the Pharmaceutical press, London; Tetrahydroanthracene glucosides in callus diffusion method.

They observed the maximum tissue from Aloe barbadensis leaves. Klein AD, Penneys. Aloe vera. The maximum antifungal activity was 4. Eshun K, He Q. Herbs for Health magazine ; 23 extracts. Pawar et al prepared the crude A. Foster S. Aloe vera, The succulent with skin Internet Journal of Microbiology.

Davis HR. The second phase involves the removal of dead tissue and the third phase of proliferation includes epithelial regeneration and fibrous tissue formation. Aloe vera is a medicinal plant traditionally used since BC in many countries such as Greece, China, and Mexico. It also has been used for centuries as a traditional medicine for various diseases and skin lesions. It belongs to the Liliaceae family; it is similar to Cactus and is an herbaceous and perennial plant with thick, fleshy and long leaves.

The Egyptian queens Nefertiti and Cleopatra used Aloe vera as part of their regular beauty regime. Aloe vera is effective in inhibiting inflammatory reactions by the inhibition of IL-6 and IL-8, the reduction of leukocyte adhesion, an increase of IL levels, and decrease of TNF alpha levels.

Glucomannan affects fibroblast growth factor receptors and stimulates their activity and proliferation, which in turn increases the production of collagen. Aloe vera gel can not only increase the amount of collagen in wounds but also change the composition of collagen, increase collagen cross-linking and thereby promote wound healing.

Considering the availability of several clinical trials on the effect of Aloe vera on the prevention and healing of skin wounds, as well as its popularity among people and widespread use in the cosmetic industry, the present study aimed to review research studies on this topic.

The present study is a review of clinical trials on the effect of Aloe vera in preventing and healing of skin wounds. Articles published in both national and international journals were considered. Moreover, the references of the identified articles were searched for additional sources of information. The used keywords were Aloe vera, wound healing, and prevention. All keywords were searched electronically, the titles and abstracts of all identified articles were screened, and duplicated articles were omitted.

Each article was independently screened by four reviewers and possible disagreements were resolved in a joint review meeting. The language of the articles was either Persian or English. The sample size of at least 30 cases was considered sufficient.

All studies using animal models, lack of access to full text, lack of transparency of statistical results, and sample size less than 30 cases were excluded. Articles that were performed on animals, duplicated articles, non-transparent statistical results without mean, standard deviation, confidence interval, test, P value, etc. Eventually, 23 trials that met the inclusion criteria were studied figure 1. In total, 57 articles were identified out of which 16 were conducted on animals, 2 lacked access to the full text, 10 lacked transparency of statistical results, and 6 had a sample size less than 30 cases.

These articles were removed and eventually, 23 articles were evaluated. Wound healing and preventive effects of Aloe vera have been reported in several studies. Aloe vera is considered as the traditional therapy for burns. Five studies investigated burn wound healing.

Moreover, it reduced the recovery time, prevented infection in the wound area, and prevented redness and itching. As described in Table 2 , Aloe vera was used on postoperative wounds such as episiotomy, cesarean section, skin biopsy, hemorrhoidectomy, gynecologic laparotomy surgery, and graft. Only one study group, Aloe vera dressing for skin shave biopsy, did not show any difference in terms of improvement compared to the combined dressing group.

As described in Table 3 , Aloe vera was used for healing of cracked nipples in 2 studies and it reduced the pain and discharge in the area. Aloe vera has been effective in chronic wounds such as pressure ulcers, diabetic ulcers, chronic anal fissure wounds, chronic wounds caused by accidents, psoriasis, and genital herpes. In this regard, 7 articles were studied and Aloe vera was more effective compared to saline gauze dressing, phenytoin, and current treatments. Aloe vera has also been effective in the prevention of ulcers.

Mucopolysaccharides along with amino acids and zinc available in Aloe vera can lead to skin integrity, moisture retention, erythema reduction, and helps to prevent skin ulcers. As described in Table 5 , two studies were reviewed. Based on a detailed review of articles, the application of Aloe vera as a medicinal plant for skin wound healing is confirmed. It has resulted in reduced recovery time, the absence of wound infection, and the lack of redness and itching. The outcome of the present review study shows that Aloe vera is unanimously considered as the ideal dressing.

Most studies have been performed on grade 1 and 2 ulcers and there are limited studies on grade 3 ulcers. The latter could be due to full thickness skin loss in grade 3 wounds and possible onset of wound infection.

Aloe vera gel or cream on postoperative wounds three times a day for days could reduce pain and recovery time. Cracked nipples could also be treated using Aloe vera if applied 3 times a day or after each breastfeeding. It would reduce the pain due to cracked nipples.

It is indicated that Aloe vera as a gel or cream can be effective to treat chronic wounds such as psoriasis lesions twice a day for weeks , 34 , 37 pressure ulcers months , venous, diabetic, 31 , 32 and herpes ulcers and chronic anal fissure weeks.

Only Thomas and colleagues found no healing difference between saline and Aloe vera in the treatment of pressure ulcers. Perhaps the small sample size 30 cases was the reason behind their findings. They indicated that Aloe vera is superior to other treatments.

Several studies noted the traditional belief that a wound should not be covered, allowing it to become dry and detach itself from the wound area since it inhibits the migration of cells and growth factors leading to wound healing.

Aloe vera as a wound cover would keep the wound area moist and allows optimal migration of fibroblasts and epidermal. The main limitations of the present systematic review were the quality of available literature, lack of access to all articles, and unpublished reports. Moreover, only the literature in English and Persian were reviewed. These have considerably reduced our sample size regarding various data parameters and consequently hindered our ability to determine statistically significant results.

Furthermore, not all articles were blind experiments, which is a challenge to determine the true effect of Aloe vera on wound healing. In total, 57 articles had to be excluded since they involved multiple procedures or multiple indications without providing specific outcomes data for the Aloe vera effect on wound healing. Since the present study was not a meta-analysis and had no major summary, data analysis to determine publication bias with the STATA software was not performed.

However, qualitative analysis of both the survey responses and the focus group discussion identified possible ways of reducing publication bias. This was done through increased transparency, improvements in trial registries, search engines and databases, enhancing the role of the institutional review boards, and positive support from the scientists. The above-mentioned approaches minimized publication bias. Due to the properties of Aloe vera and its compounds, it can be used to retain skin moisture and integrity.

It also prevents skin ulcers as it contains mucopolysaccharides, amino acids, zinc, and water. In terms of quality and speed of wound healing, Aloe vera is much more effective and less costly compared to the currently available alternative treatments. Considering the tendency to promote traditional medicine as well as rare side effects of Aloe vera, the use of this medicinal plant to improve wound healing is recommended as the complementary treatment alongside other methods.

Conflict of Interest: None declared. National Center for Biotechnology Information , U. Iran J Med Sci. Author information Article notes Copyright and License information Disclaimer. E-mail : ri. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC.

Abstract Background: Aloe vera is an herbaceous and perennial plant that belongs to the Liliaceae family and used for many medicinal purposes. Results: In total, 23 trials that met the inclusion criteria were studied. Conclusion: Considering the properties of Aloe vera and its compounds, it can be used to retain skin moisture and integrity and to prevent ulcers. Introduction The process of wound healing is a complex biological process and promotion of tissue recovery is the main objective of medical interventions.

Materials and Methods Search Strategy The present study is a review of clinical trials on the effect of Aloe vera in preventing and healing of skin wounds. Inclusion Criteria All clinical trials using Aloe vera gel, cream, or derivatives that included a control group with placebo or comparison with other treatments were included in the study.

Exclusion Criteria All studies using animal models, lack of access to full text, lack of transparency of statistical results, and sample size less than 30 cases were excluded.

Open in a separate window. Results In total, 57 articles were identified out of which 16 were conducted on animals, 2 lacked access to the full text, 10 lacked transparency of statistical results, and 6 had a sample size less than 30 cases.

Parameters of the wound on the 1 st , 7 th , and 15 th days were studied using Bates-Jensen wound assessment tool. Finally, it was reported that wounds healed faster using Aloe vera gel dressing than silver sulfadiazine Khorasani et al.

In both groups, Aloe vera and sulfadiazine were applied twice a day. The healing time was 19 days. Email: webcenter niehs. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public.

Email: ods nih. This publication is not copyrighted and is in the public domain. Duplication is encouraged. NCCIH has provided this material for your information. It is not intended to substitute for the medical expertise and advice of your health care provider s. We encourage you to discuss any decisions about treatment or care with your health care provider.

Home Health Information Aloe Vera. Aloe Vera. Common Names: aloe. Aloe is a cactus-like plant that grows in hot, dry climates. It is cultivated in subtropical regions around the world, including the southern border areas of Texas, New Mexico, Arizona, and California. Historically, aloe has been used for skin conditions and was thought to improve baldness and promote wound healing.

Aloe is used topically applied to the skin and orally. Topical use of aloe is promoted for acne, lichen planus a very itchy rash on the skin or in the mouth , oral submucous fibrosis, burning mouth syndrome, burns, and radiation-induced skin toxicity. In , the U.

Food and Drug Administration issued a ruling that required manufacturers to remove aloe from over-the-counter laxative products because of a lack of safety data. How Much Do We Know? A number of studies have investigated the usefulness of aloe as a dietary supplement or a topical product for health purposes in people.

What Have We Learned?